- Brendan Gleeson as Bill Hodges
- Harry Treadaway as Brady Hartsfield
- Kelly Lynch as Deborah Hartsfield
- Jharrel Jerome as Jerome Robinson
- Scott Lawrence as Peter Dixon
- Robert Stanton as Anthony Frobisher
- Breeda Wool as Lou Linklatter
- Justine Lupe as Holly Gibney
- Mary-Louise Parker as Janey Patterson
- Holland Taylor as Ida Silver
- Ann Cusack as Olivia Trelawney
- Katharine Houghton as Elizabeth Wharton
- Makayla Lysiak as Barbara Robinson
- "Pilot (Mr. Mercedes)"
- "On Your Mark"
- "Cloudy, With a Chance of Mayhem"
- "Gods Who Fall"
- "The Suicide Hour"
- "People in the Rain"
- "Willow Lake"
- "From the Ashes"
- "Ice Cream, You Scream, We All Scream"
- "Jibber-Jibber Chicken Dinner"