Mary Jackson is a college professor and the wife of Peter Jackson in Desperation. She and her husband are stopped by Collie Entragian outside of Desperation, Nevada for not having a license plate. Collie finds a bag of marijuana in the trunk of the car and takes Mary and Peter prisoner. Peter is killed by Collie, but Mary is one of God's chosen to stop Tak. She survives the battle and leaves the cursed town with the other survivors.