Lisey's Story is the story of Lisey (pronounced LEE-see) Landon, who is the widow of a famous and wildly successful novelist, Scott Landon. The book tells two stories--Lisey's story in the present, and the story of her dead husband's life, as remembered by Lisey during the course of the novel.
It has been two years since her husband's death, and Lisey is in the process of cleaning out her dead husband's writing area. A series of events occurs that causes Lisey to begin facing certain realities about her husband that she had repressed and forgotten. As Lisey is stalked, terrorized, and then mutilated by an insane fan of her husband's, Lisey begins recalling her husband's past--how he came from a family with a history of horrible mental illness that manifested as either an uncontrollable homicidal mania or as a deep catatonia, how he had a special gift, an ability to transport himself to another world, called by Scott Landon "Boo'ya Moon," how Scott Landon's brother was murdered by his father when his brother manifested an incurable insanity, and finally how Scott Landon murdered his father to save his father from the madness that had finally taken him over.
As the novel progresses we see the complexity of Lisey's marriage to Scott, and their deep and abiding love for each other. The novel takes place over a very short period of time--a matter of days--but the real story is told in Lisey's remembrances of her husband, her ability to harness his special power to save herself (and her sister), and finally to find the gift that her dead husband had left for her in Boo'ya Moon--a story just for Lisey. Lisey's story.
- One of the antagonists of the novel, Jim Dooley, comes from the ( fictional ) town of Shooter's Knob, Tennessee, which is the same town that Ted Milner comes from in Secret Window, Secret Garden. Dooley also shares some characteristics with the main antagonist of that novella, John Shooter.