The story is set in the small town of Tarker's Mill, Maine. A werewolf is viciously killing people and animals, and a strange incident takes place at each full moon. The otherwise normal town is living in fear. The protagonist of the story is Marty Coslaw, an eleven-year-old boy in a wheelchair. The story goes back and forth from the terrifying incidents to Marty's youthful day-to-day life and how the horror affects him.
The story was adapted into a film in 1985.
The audiobook version of Cycle of the Werewolf is read by Nick Sullivan.