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Captain Trips is a nickname for the constantly shifting antigen virus that exterminates 99.4% of the human population in The Stand.
Developed under the code name Project Blue by a biological weapon's laboratory located beneath California's Mojave Desert, it is also known as Blue virus (Blue Virus), A-prime, A6, the rales, superflu, and tube neck.
The virus is set loose on the population when Charlie Campion, who was working in the base that developed it, noticed that the virus had been released in the base and managed to escape with his wife and daughter, but not before being infected with it himself. He carried the virus all the way to Arnette, Texas, before dying, thus setting in motion the events of the novel.